Selective serotonin reuptake inhibitors (SSRIs) are globally popular antidepressants. But they increase dental implant failure! Recent studies by McGill University and NIH further supported precious evidence about SSRIs having negative effects on bone, particularly in bone mineral density and fracture. According to an article done by the Journal of dental Research, anti-depressant use is tied to risk of Osseo integrated implant failure.
Since Osseo integration is influenced by bone metabolism, this study was done to examine the relationship between SSRIs and the risk of failure. The study was conducted on patients treated with dental implants from January 2007 to January 2013. A total of 916 dental implants in 490 patients (94 implants on 51 patients using SSRIs).
After 3 to 67 months of follow-up, 38 dental implants failed and 784 succeeded in the nonusers group, while 10 failed and 84 succeeded in the SSRI-users group. The outcome was that compared with nonusers of SSRIs, SSRI usage was associated with an increased risk of dental implant failure. The failure rate was 4.6% for SSEI nonusers and 10.6% for users. A secondary outcome was that small implant diameters (less than 4mm) and smoking habits also seemed to increase risk of implant failure. Their findings indicate that treatment with SSRIs is related to an increased failure risk of implant failure.